A Deep Dive into DNA Base Pairing Interactions Under Water


Base pairing plays a pivotal role in DNA functions and replication fidelity. But while the complementarity between Watson–Crick matched bases is generally believed to arise from the different number of hydrogen bonds in G|C pairs versus A|T, the energetics of these interactions are heavily renormalized by the aqueous solvent. Employing large-scale Monte Carlo simulations, we have extracted the solvent contribution to the free energy for canonical and some noncanonical and stacked base pairs.

In The Journal of Physical Chemistry B
Rongpeng Li (Ron)
Rongpeng Li (Ron)
Business Intelligence Engineer & Author & Speaker

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